Jackson ImmunoResearch focuses their antibody development on secondary antibodies. Their range of products includes antibodies for flow cytometry, primary antibodies that are used for signal enhancement, and whole lgG affinity-purified antibodies.
The whole lgG affinity-purified antibodies are supported for numerous target species that include mouse, rabbit, sheep, rat, human, cat, chicken, and dog. This group of antibodies includes several types of applications. The anti-mouse lgG subclass antibodies group is used to differentiate multiple subclasses of the mouse lgG in numerous experiments. They can also be used to determine the lgG mouse subclass. The R-PE, APC, and PerCP conjugates are proteins for flow cytometry. Other categories of whole lgG affinity-purified antibodies include anti-light chain-specific antibodies, Alex Fluor® 680 and Alexa Fluor® 790 antibodies, Cyanine dyes, colloidal gold reagents, and antibodies for signal enhancement.
Jackson ImmunoResearch monovalent fab fragment affinity-purified antibodies block immunoglobulins of endogenous type that is found in sections of tissue and on the surfaces of cells. The target species for these affinity-purified antibodies are sheep, human, goat, mouse, rat, and rabbit.
Jackson ImmunoResearch provides numerous streptavidin conjugates for a variety of applications. These applications include flow cytometry, immunoassays, procedures associated with immunoblotting. The recommended usage for these products is with Biotin-SP-conjugated ChromPure proteins and Biotin-SP-conjugated affinity-purified secondary antibodies.
The Jackson ImmunoResearch peroxidase-anti-peroxidase (PAP) soluble immune complexes are products that are developed according to a documented method. This group of complexes are comprised of a combination of anti-horseradish peroxidase antibodies and molecules of the same type. The PAP soluble immune complexes have a variety of applications, but are not considered to be suitable for cell research projects that involve endogenous peroxidase activity that has been determined to be a challenge to control.
Primary antibodies are useful for enhancing signals. Jackson ImmunoResearch offers IgG fraction Monoclonal Mouse Anti-Biotin, Anti-Digoxin, and Anti-Fluorescein that are commonly used as direct conjugates. Another use of these antibodies in an unconjugated form is for signal enhancement.
ChromPure proteins are a group of products that Jackson ImmunoResearch develops using several methods that include hydrophobic, gel-filtration, and ion-exchange. These antibodies are unique in that they not raised for a specific antigens. Due to this characteristic, they are considered as only controls for experimental purposes.
The bovine serum albumin (BSA) products are popular offerings for Jackson ImmunoResearch. These proteins serve a significant purpose to researchers. They are used to minimize the concentration of antibodies and block proteins in protocols for immunodetection and immunoassays. In contrast to common practices, Jackson ImmunoResearch produces BSA proteins that are free of IgG, which is commonly generated in a manner that causes interactions that affect the efficiency of the antibodies. In addition to being free of IgG, these Jackson ImmunoResearch proteins are also free of protease. As a final step in purifying the proteins, Jackson ImmunoResearch also freeze-dries them with water that is deionized. The result of this uncommon generation of BSA is fewer interactions, which leads to better antibody activity.
The antisera product group are developed to bridging PAP to specific primary antibodies. While there are several benefits of this product type, they are not one of the most common products for Jackson ImmunoResearch.
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My other passions include grilling, wine tasting, and real food. To be honest, my biggest passion is flow cytometry, which is something that Carol and I share. My personal mission is to make flow cytometry education accessible, relevant, and fun. I’ve had a long history in the field starting all the way back in graduate school.